Everything that worked so well on opening day turned sour on day two as the Red Sox lost to the Cleveland Indians 7-6. It starts with Clay Buchholz.

He lasted just four innings, throwing 94 pitches. Buchholz gave up five runs on six hits, walked three while striking out four.

Noe Ramirez and Junicha Tazawa gave up runs out of the bullpen.

Hanley Ramirez didn't look so good at times at first base.

On the positive side, David Ortiz hit another homer and then Ramirez made it back-to-back.

In the end, former Sox Mike Napoli turned out to be the difference maker - a seventh inning home run that gave the Tribe the lead for good.